It is a complicated movie about two best friends who happens to come face-to-face with their look-alikes. Best friends Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh) both are unaware about their lookalikes Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh), who are also best buddies who are also not aware of their lookalikes Ashok (Saif Ali Khan) and Kumar (Riteish Deshmukh), again both are best buddies. Mamaaji (Ram Kapoor) is a lookalike of another Mamaaji (Ram Kapoor) who in turn is a lookalike of another Mamaaji (Ram Kapoor). In short, it\'s the story of three different individuals who have two other lookalikes of each one of them.
The opening credits of this movie pay tributes to Kishore Kumar and Jim Carrey. The movie opens in an asylum. UK-based business tycoon Singhania is trapped by his evil uncle played by Ram Kapoor. Ram Kapoor, the conniving uncle intends to tarnish Ashok (Saif Ali Khan\'s) fortune by declaring him insane. Deliberately injecting a green-coloured liquid, Ashok and Kumar starts showing canine tendencies resulting them in their incarceration at a mental hospital named by Cray G. The mental asylum is run by a bunch of insane jerks with strange treatment methods.
Then so happens a coincidental goof-up that the other Ashok-Kumar pair that regresses back to childhood for lame reasons. Ashok and Kumar (pals since second standard) whose look-alikes with exactly the same names are locked up in a mental asylum and third link to their story is their look-alike with the same names. Alike them, Mamaaji too has his triple roles. None of these people are aware about them having 2 other look-alikes. It is that then their look-alikes are also lodged in the neighbouring ward with the exactly the same names. The second pair is annoying and their arrested development gets them transformed into annoying kids. Then there is the final and third pair of look-alikes (effeminate gays) that gets unfolded post interval. The female leads Esha Gupta, Tamannaah Bhatia and Bipasha Basu romances with Ashok and Kumar. The present situation begins with its twists when each of their lookalikes enters the scenario booming the current confusion.