Ram Parmar ( Ayushman Khurana) meets Mandar Lele ( Kunaal Roy Kapur) at one night. Mandar is a troubled and lonely guy. Nautanki Saala! is a tale of a bonding and friendship between these two guys. It's a comedy of errors where Ram Parmar's all acting skills are tested to the limits as he manages his way through an entertaining real life drama which is complimented by a powder keg time bomb named Mandar Lele.