The four characters who are worthless means of no use are the funny people from Dhamaal  Roy (Ritesh Deshmukh), Adi (Arshad Warsi), Manav (Jaaved Jaaferi) and Boman (Aashish Chaudhry) who have come back once more in this movie! These four characters are till now as stupid and idiot as they were in their previous film. They do not believe in hard work and want to live easy life and get everything without doing anything. However they are expert in telling lies and this is the only job they have done till now and continue doing further.

All these four characters lie down on their backside and daydream to achieve all comforts and luxuries of their lives and have a good life and all these things they want to get without doing anything!

But all of a sudden they happen to see their old arch foe who is none another than the dishonest and corrupt Inspector Kabir Nayak (Sanjay Dutt). But he is not any more a police inspector and in this movie he is after money instead of hunting criminals.

He is chasing money and he drives a Mercedez and he also possesses a high-class office and a lavish cottage. These four stupid characters are jealous of the luxurious life and status of Kabir and they think that by hook or by crook they would also share the good fate of Kabir. To fulfil their desire they start blackmailing Kabir and press him that he should make them his partner in his business.

Something happens which bring them joy and happiness and their happiness knows no bounds because according to them everything was going as they had wished and which would turn their dreams true.

But they are unaware of the fact that it was not what it appeared to be! Something else was disguised in some other from. Some incidents are going to take place which are going to turn their dreams into nightmares because Kabir has his own hidden agenda which he shared only shared with his hot wife Kamini (Mallika Sherawat) and pretty sister Kiya (Kangna Ranaut). And thereafter begins a game of 1 up man ship, in which both the sides have tricks up their sleeves and where miscellaneous characters like Batabhai (Satish Kaushik) and King of Casino Johnny Bonzola, are introduced up to make the lives of the four stupid fellow miserable. And of course, there is a hell.. a lot of money at hazard.
 
There are also too many twists and turns and a bellyful of smiles and laughter. But who would be seen to having the last laugh? Would it be Kabir or the four stupid characters whom  you would start loving from the start.