Presumed death, RAW agent Tiger (Salman Khan) and ISI agent Zoya (Katrina Kaif) are blissfully married and living a peaceful life with their son, Junior. It has been eight long years since they decided to leave their past behind and lead a normal life in the beautiful city of Innsbruck, Austria. But destiny has some other plans in store for them. RAW head Shenoy (Girish Karnad), who never tried to contact Tiger in these many years, finds his whereabouts only to engage him in a new mission - the mission of rescuing 25 Indian nurses held hostage in a hospital by Abu Usman, the head of terrorist organization ISC, in Ikrit, Iraq. Tiger takes on the mission and builds his own team that helps him throughout. Soon Zoya also joins the deadly mission as, besides 25 Indian nurses, there are 15 Pakistani nurses who are also held hostage with the Indian nurses and need to be rescued before the U.S. bombs the hospital and kills ISC head, Abu Usman. Using all their vim and vigor, Tiger and Zoya save the nurses, saving the honor of their respective countries.